What Is Regenerative Medicine?

Regenerative Medicine is the use of one’s own cells to help promote healing and decrease pain. The procedure allows the body’s own mechanism to release growth factors to improve range of motion and quality of life.

Who Is A Candidate For This Procedure?

The ideal recipient is one that wants their body’s own potential as an option to possibly delay and or prevent surgery.

What Are The Ideal Joints To Inject?

  • Problems of the knee including osteoarthritis, meniscal tears, bursitis.
  • Problems of the hip including osteoarthritis, labral tears, bursitis.
  • Problems of the shoulder including osteoarthritis, partial rotator cuff tears, bursitis.

Platelet Rich Plasma Therapy Procedure

In the procedure, the physician will aspirate tissue to harvest some of your  cells. Because your own cells are used, the procedure is considered to be “autologous point-of-care.” Platelet-rich plasma is obtained from your blood. The combination of these two are injected into the painful joint.

What Can I Expect From the Treatment?

The procedure is performed in the medical office. Most cases of PRP treatments are successful, and avoid the pain, inability, down time, and risk associated with major surgery. There is minimal recovery from the procedure. Patients return to work the following day. There are no sutures required.

When Can I Resume Physical Activity?

The most important part of any regenerative medicine therapy procedure is adhering to your post-procedure restrictions. For this procedure to have the best chance to yield lasting benefits one must:
• Avoid anti-inflammatory medications for two weeks post-procedure
• Rest as much as possible for the first 24 – 48 hours
• Restrict activity to general walking only for 2 – 3 weeks
• After 4 weeks, weightlifting and running are permitted.

A. Disease Background
1) Brooks P. The burden of musculoskeletal disease – a global perspective. Clin Rheumatol. 2006; 25:778-781.
2) Longo, Fauci, Kasper, Hauser, Jameson, Loscanzo, editors. Harrison’s Principles of Internal Medicine, 18th Edition. New York: McGraw Hill Medical, 2012 pp.2828-2836.
3) Sarzi-Putini P, et al. Osteoarthritis: An overview of the disease and it treatment strategies. Semin Arthritis Rheum. 2005; 35:1-10
6) Lacitignola L, et.al. Cell therapy for tendonitis, experimental and clinical report. Vet Res Commun. 2008; Sup: 32 suppl 1: S 33-8.
7) Renzi S, et al. Autologous bone marrow mesenchymal stromal cells for regeneration of injured equine ligament and tendons: a clinical report. Res Vet Sci. 2013 Aug 95(1):272-7.
8) Centeno CJ, et al. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal cells. Pain Physician 2008: 11(3):343-353.
9) Emadedin M, et al. Intra-articular injection of autologous mesenchymal cells in six patients with knee osteoarthritis. Anthroscopy 2013: 29(4): 748-55.

E. Platelet Rich Plasma
1) Bielecki TM, et al. Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances. J Bone Joint Surg BR. 2007-89-B: 417-20.
2) Chen L, et al. Antibacterial eǺect of autologous platelet-rich gel derived from subjects with diabetic dermal ulcers in vitro. J Diabetes Res 2013:doi. org/10.1155/2013/269527
3) Burnouf et al. Antimicrobial activity of platelet (PTLpoor Transfusion. 2013; 531(1):138-46 PLT lysate biomaterials against wound bacteria. Transfusion, 2013; 53(1) 138-46.
4) Yang Y. et al Antibacterial effect of autologous platelet-rich gel derived from health volunteers in vitro. Zhonggus Xiu Fu Chong Jian Waike Za Zhi. 2010;24(5):571-6.

F. Diagnostic Assessment
1) McConnells, et al. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); a review of its utility and measurement properties. Arthritis Rheum 2001; 45(5):453-461.
2) Raman J. Macdermid JC, Western Ontario Rotator Cu Index. Journal of Physiotherapy. 2012:58:102.
3) Meenan RF, German PM Mason JH. Measuring Health status in arthritis: the Arthritis Impact Measurement Scale. Arthritis Rheumatism 1980:23:146-52.
4) Ren XS, Kazis L. Meenan RF. Short-form Arthritis Impact Measurement Scale 2: tests of reliability and validity among patients with osteoarthritis. Arthritis care Res. 1999; 12(3): 163-71.

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Contact Healthy Aging Medical Centers in New Jersey at 973.435.0433 for a consultation to learn how regenerative therapy can reduce pain and promote healing in areas like the knee, hip and shoulder.